Fucoidan Mechanism of Action

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Mechanism of Action
Fucoidan has been shown to inhibit metastasis by preventing adhesion of tumor cells to the extracellular matrix. This is achieved by blocking the fibronectin cell-binding domain, necessary for formation of adhesion complexes (4). Fucoidan was also shown to induce apoptosis of human T-cell leukemia virus type I (HTLV-1) that causes Adult T-cell leukemia. It does so by inactivating NF-kB that regulates antiapoptotic proteins. It suppresses AP-I, a transcription factor involved in cellular proliferation and transformation (3). An vitro study showed that Fucoidan can suppress angiogenesis induced by Sarcoma 180 cells in mice (5). Fucoidan has immunomodulating effects and enhanced the activity of NK cells, which play a crucial role in mediating tumor cell death (2). The neuroprotective effects of fucoidan are attributed to its ability to suppress tumor necrosis factor-alpha (TNF-alpha)- and interferon-gamma (IFN-gamma)-induced NO production in C6 glioma cells (11) and to its antioxidative effects (12).

This entry was posted on Tuesday, February 15th, 2011 at 4:14 pm and is filed under Cancer. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

2 Responses to “Fucoidan Mechanism of Action”

  1. James Says :

    Dr. Emch have you tested many fucoidan products? I recommend a japanese supplement umi no shizuku fucoidan. My friend Sun Kim is taking this same one, she has brain cancer. She had two large tumors one on each side but after a year her right tumor disappeared and the left shrunk a lot. I hope you can take some time to check it out maybe it can help others as well.

  2. Mallory Hobbs Says :

    I also have a great source of Fucoidan, it is am amazing product called Limu. The fucoidan is extracted in a chemical free process from the seaweed Lumi Moui, which has the highest concentration of fucoidan. If you would like additional info please feel free to contact me at the e-mail address provided. or call my cell at (256)404-8123. The results from this product that I have witnessed are absolutely amazing and mind blowing. I would also like to know more about how fucoidan interacts with the human body and how it helps on a chemical level, besides just with cancer cells and I believe you could help me with that. Thank you!

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