Information on Graviola from Sloan-Kettering

Constituents
Acetogenins, quinolines, isoquinolines, annopentocins and annomuricins (7). Coreximine and reticuline subfractions have been isolated from root bark (6).
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Mechanism of Action
Annonaceous acetogenins, a phytochemical isolated from the leaves, bark and twigs of graviola, are thought to be the active ingredient. The ethanolic extract of Annona muricata was found to inhibit the Herpes simplex virus (1). The ethyl acetate extract was found to be more active than the methanolic or hexanolic extracts. Extracts were shown to be effective against Leishmania braziliensis, L. panamensis promastigotes and the cancer cell line U 937 (3) and hepatoma cell lines(8) in vitro. Extracts were also shown to be lethal to the fresh-water mollusk Biomphalaria glabrata, which acts as a host for the parasitic worm Schistosoma mansoni (2). Alkaloids from graviola have been shown to be detrimental to the survival of dopaminergic nerve cells in vitro. This may in turn lead to neuronal dysfunction and degeneration. Graviola-induced cell death was inhibited by the supplementation of glucose suggesting that cell death was caused by energy depletion (6). Graviola extracts have also been shown to be effective against the growth of Adriamycin resistant human mammary adenocarcinoma (MCF-7/Adr) by blocking the cancer cell’s access to ATP and by inhibiting the actions of plasma membrane glycoprotein (5). Graviola may also have antidepressive activity due to its ability to stimulate serotonine receptors (7).

This entry was posted on Thursday, February 17th, 2011 at 7:44 pm and is filed under Cancer. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

2 Responses to “Information on Graviola from Sloan-Kettering”

  1. John Gronbeck-Tedesco Says :

    I was just diagnosed with squamous cell skin cancer. The location is on the scalp and i’m being scheduled for Mos surgery. I’d been taking graviola in capsule form for about a month before the diagnosis–as a prophilactic. I’ve been taking about1200mgs each day out of the 3600 that are recommended on the bottle of Raintree graviola Max. How much and in what form should I take graviola for my skin cancer? How do i find out? (I’m wanting to use it as an accompaniment to treatment.)

    JGT

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